On the kinetic design of transcription.

  title={On the kinetic design of transcription.},
  author={T. H{\"o}fer and Malte J. Rasch},
  journal={Genome informatics. International Conference on Genome Informatics},
  volume={16 1},
  • T. Höfer, Malte J. Rasch
  • Published 2005
  • Medicine, Biology
  • Genome informatics. International Conference on Genome Informatics
  • We analyse a stochastic model of transcription that describes transcription initiation by promoter activation and subsequent polymerase recruitment. Explicit expressions are derived for the control of an activator on the mean mRNA number and for the mRNA noise. Both properties are strongly influenced by the kinetics of promoter activation, mRNA synthesis and degradation. Low transcriptional noise is obtained either when the transcription initiation complex has a long life-time or when its… CONTINUE READING
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