On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine.

@article{Sawynok1982OnTI,
  title={On the involvement of GABA in the analgesia produced by baclofen, muscimol and morphine.},
  author={Jana Sawynok and Frank S. Labella},
  journal={Neuropharmacology},
  year={1982},
  volume={21 5},
  pages={397-403}
}
In the mouse hot-plate test (50 degrees C), muscimol produced analgesia which was blocked by bicuculline but not by picrotoxin. Analgesia produced by baclofen was dose-dependent and stereoselective, but was not blocked by bicuculline, picrotoxin or naloxone. Morphine-induced analgesia was not altered by bicuculline. The inhibitors of GABA-transaminase, amino-oxyacetic acid, gamma-acetylenic GABA and gamma-vinyl GABA, produced analgesia which was much more prolonged than that observed with… CONTINUE READING
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