On the intracellular localization of the 3beta-hydroxysteroid dehydrogenase isomerase in the rat adrenal cortex.

@article{Kream1976OnTI,
  title={On the intracellular localization of the 3beta-hydroxysteroid dehydrogenase isomerase in the rat adrenal cortex.},
  author={Barbara E. Kream and Leonard A. Sauer},
  journal={Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine},
  year={1976},
  volume={152 3},
  pages={
          459-62
        }
}
SummaryIn this study we have compared some properties of the microsomal and mitochondrial 3β-hydroxysteroid dehydrogenase/isomerase (HSD) from the rat adrenal cortex. The following major differences were noted: (i) the microsomal enzyme required exogenous NAD while the mitochondrial enzyme was active in the absence of added NAD. (ii) The mitochondrial enzyme was inhibited by a combination of rotenone, KCN, and citric acid cycle substrates. These agents did not influence the activity of the… CONTINUE READING
BETA