On the intra-host dynamics of HIV-1 infections.

  title={On the intra-host dynamics of HIV-1 infections.},
  author={Nikolaos I. Stilianakis and Dieter Schenzle},
  journal={Mathematical biosciences},
  volume={199 1},
An extension of a previously proposed theory for the pathogenesis of AIDS is presented and analyzed using a mathematical modelling approach. This theory is based on the observation that human immunodeficiency virus type 1 (HIV-1) predominantly infects and replicates in (CD4+)-T cells, and that the infection process within an infected individual is characterized by ongoing generation and selection of HIV variants with increasing reproductive capacity. This evolutionary process is considered to… CONTINUE READING
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