On the interpretation of binding isotherms in complex biological systems. Apparent homogeneity of some heterogeneous systems.

@article{Minton1979OnTI,
  title={On the interpretation of binding isotherms in complex biological systems. Apparent homogeneity of some heterogeneous systems.},
  author={Allen P Minton},
  journal={Biochimica et biophysica acta},
  year={1979},
  volume={558 2},
  pages={179-86}
}
A simple treatment of the effect of site heterogeneity upon binding isotherms is presented, which is applicable to the analysis of data obtained from measurements of hormone, drug, or lectin binding to membranes and cell surfaces. Using this treatment, isotherms corresponding to various distributions of binding constants have been fitted to examples of… CONTINUE READING