On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2.

@article{Parren1992OnTI,
  title={On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2.},
  author={Paul W H I Parren and Petra A. M. Warmerdam and Leonie C. M. Boeije and Janine Arts and Nomdo Anton Christiaan Westerdaal and A. M. C. Vlug and Peter J. A. Capel and Lucien A. Aarden and J G J van de Winkel},
  journal={The Journal of clinical investigation},
  year={1992},
  volume={90 4},
  pages={1537-46}
}
An allotypic form of the low affinity IgG Fc receptor Fc gamma RIIa (CD32), termed low responder (LR) because of its weak reactivity with mouse (m) IgG1, interacts efficiently with human (h) IgG2. Fc gamma RIIaLR is the first known human FcR that binds this IgG subclass. In this study, we analyzed the role of Fc gamma RIIa in binding of stable hIgG-subclass dimers, and in induction of T cell mitogenesis using chimeric anti-CD3 mAb. We demonstrate that the functional polymorphism to hIgG2 is… CONTINUE READING