On the inheritance of the split hand/split foot malformation.

  title={On the inheritance of the split hand/split foot malformation.},
  author={Jo{\"e}l Zlotogora},
  journal={American journal of medical genetics},
  volume={53 1},
Analysis of families with non-syndromal split hand/split foot (SHSF) confirms the existence of 2 distinct entities, most probably caused by at least 2 different autosomal dominant genes. In the families in which the SHSF malformation is non-syndromal and limited to the hands and feet (type I), the pattern of inheritance is of a regular autosomal dominant gene with a high penetrance (96%). In families in which at least one individual has other limb malformations and SHSF (type II), the… CONTINUE READING


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