On the influence of the substrate (elastin) in elastase-alpha 1 antitrypsin interactions.


Evidence is presented showing that elastin(s) influences the interactions between porcine pancreatic elastase and its main plasma inhibitor alpha 1-proteinase inhibitor (e.g. alpha 1 antitrypsin). The rate constant of association (kon) between the proteinase and alpha 1 antitrypsin is decreased from 2.8 10(5) M-1 sec-1 to 1.24 10(5) M-1 sec-1 in presence of… (More)


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