On the influence of extracellular fluid volume expansion and of uremia on bicarbonate reabsorption in man.

@article{Slatopolsky1970OnTI,
  title={On the influence of extracellular fluid volume expansion and of uremia on bicarbonate reabsorption in man.},
  author={Eduardo M Slatopolsky and Philip E Hoffsten and Mabel L. Purkerson and Neal S. Bricker},
  journal={The Journal of clinical investigation},
  year={1970},
  volume={49 5},
  pages={988-98}
}
The patterns of bicarbonate reabsorption during increasing plasma concentrations were studied in subjects with a range of glomerular filtration rates (GFR) from 170 to 2 ml/min. In a group of five subjects with GFR values above 30 ml/min, paired bicarbonate titration studies were performed first under conditions which minimized extracellular fluid (ECF) volume expansion, and second under conditions which were conducive to exaggerated expansion of ECF volume. In patients with GFR values below 30… CONTINUE READING

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