On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.

@article{FaraldoGmez2007OnTI,
  title={On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases.},
  author={Jos{\'e} D. Faraldo-G{\'o}mez and Beno{\^i}t Roux},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 34},
  pages={13643-8}
}
Regulation of signaling pathways in the cell often involves multidomain allosteric enzymes that are able to adopt alternate active or inactive conformations in response to specific stimuli. It is therefore of great interest to elucidate the energetic and structural determinants that govern the conformational plasticity of these proteins. In this study, free-energy computations have been used to address this fundamental question, focusing on one important family of signaling enzymes, the Src… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.

Protein Sci 15:65–73

  • JM Hochrein, EC Lerner, AP Schiavone, TE Smithgall, JR Engen
  • 2006

Similar Papers

Loading similar papers…