On the immortality of the germ line: Genetic and biochemical mechanisms. A review

@article{Medvedev1981OnTI,
  title={On the immortality of the germ line: Genetic and biochemical mechanisms. A review},
  author={Zhores A. Medvedev},
  journal={Mechanisms of Ageing and Development},
  year={1981},
  volume={17},
  pages={331-359}
}
  • Z. Medvedev
  • Published 1 December 1981
  • Biology
  • Mechanisms of Ageing and Development
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    Moscow University Biological Sciences Bulletin
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TLDR
The problem of germ line “immortality,” which was already formulated by A. Weismann at the end of the 19th century, is reviewed and can be reduced mainly to the existence of a number of barriers that do not allow progeny to emerge from “old” germ cells, although certain “rejuvenating” processes in the gametes still go.
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The germ-line of species is immortal, at least in the sense that an unbroken continuity extends backwards in time to the origin of terrestrial life and forwards in time to an indeterminate future.
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TLDR
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The Deprivation Syndrome is the Driving Force of Phylogeny, Ontogeny and Oncogeny
TLDR
The conservation of transduction pathways and functional homology of effector molecules clearly bear witness that the principles of life established during prokaryotic and eukaryotic unicellular evolution, although later diversified, have been unshakably cast to persist during metazoan phylogenesis.
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