On the immortality of the germ line: Genetic and biochemical mechanisms. A review

  title={On the immortality of the germ line: Genetic and biochemical mechanisms. A review},
  author={Zhores A. Medvedev},
  journal={Mechanisms of Ageing and Development},
  • Z. Medvedev
  • Published 1 December 1981
  • Biology
  • Mechanisms of Ageing and Development
The Immortality of the Germ Line: The Neverending Story
  • A. Khokhlov
  • Medicine
    Moscow University Biological Sciences Bulletin
  • 2019
The problem of germ line “immortality,” which was already formulated by A. Weismann at the end of the 19th century, is reviewed and can be reduced mainly to the existence of a number of barriers that do not allow progeny to emerge from “old” germ cells, although certain “rejuvenating” processes in the gametes still go.
Germline passage of mitochondria: quantitative considerations and possible embryological sequelae.
It is proposed that maintaining the integrity of mitochondrial inheritance is such a strong evolutionary imperative that features of ovarian follicular formation, function, and loss could be expected to have been primarily adapted to this special purpose.
Germline passage of mitochondria: quantitative considerations and possible embryological sequelae
It is proposed that the mitochondria of the germline are persistently 'haploid' (effectively carrying just one mitochondrial chromosome per organelle) and this could constitute a restriction/amplification/constraint event of a type previously demonstrated for asexual purification and refinement of a nonrecombining genome.
Immortality of the germ-line versus disposability of the soma.
The germ-line of species is immortal, at least in the sense that an unbroken continuity extends backwards in time to the origin of terrestrial life and forwards in time to an indeterminate future.
Achieving immortality in the C. elegans germline
Uncoupling of pathways that promote postmitotic life span and apoptosis from replicative immortality of Caenorhabditis elegans germ cells
C. elegans germ cells retain their youthful character via alternative pathways that prevent or eliminate damage that accumulates as a consequence of cell proliferation, and germ cells of strains deficient for these activities displayed an unlimited proliferative capacity.
The Deprivation Syndrome is the Driving Force of Phylogeny, Ontogeny and Oncogeny
The conservation of transduction pathways and functional homology of effector molecules clearly bear witness that the principles of life established during prokaryotic and eukaryotic unicellular evolution, although later diversified, have been unshakably cast to persist during metazoan phylogenesis.


Loss of Genes coding for Ribosomal RNA in Ageing Brain Cells
Evidence is presented for the accumulation of single strand scissions in the DNA of ageing mouse neurones and an age-dependent increase in protein crosslinking that reflects damage to DNA accumulating during ageing.
Growth and death of diploid and transformed human fibroblasts.
It can be shown that speeding up the rate at which the error catastrophe develops, as may occur in transformed cells, can convert a population of finite life-span to one with infinite growth.
Migration of gonocytes into the mammalian gonad and their differentiation.
  • H. Peters
  • Biology
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1970
The migration of the germ cells into the mammalian gonad and their subsequent differentiation has been the subject of many investigations and controversies. However, sufficient facts have accumulated
Evolution of Sexual Reproduction: Importance of DNA Repair, Complementation, and Variation
It is argued that a complete evolutionary explanation for the maintenance of sexual reproduction should also include complementation and DNA repair.
Intrinsic mutagenesis: a genetic approach to ageing
This book is something which almost accidentally has developed very differently from how it was initially planned. The intention was to elaborate the part played by the immune system in ageing with
The origin and early differentiation of the egg chamber of Drosophila melanogaster
Hypothesis are developed to explain why stem line oogonia are restricted to the anterior portion of the germarium, why mesodermal cells first interact with cystocytes in region 2, and why the oocyte is oriented posteriorly.
Parental age effects in Drosophila pseudoobscura.