On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

Abstract

Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to the etiology of complex diseases. Hypothesis-free testing of ratios between all possible metabolite pairs in GWAS… (More)
DOI: 10.1186/1471-2105-13-120

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