On the hypes and falls in neuroprotection: targeting the NMDA receptor.

@article{Villmann2007OnTH,
  title={On the hypes and falls in neuroprotection: targeting the NMDA receptor.},
  author={Carmen Villmann and C K Becker},
  journal={The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year={2007},
  volume={13 6},
  pages={594-615}
}
Activation of the NMDA (N-methyl-D-aspartate) responsive subclass of glutamate receptors is an important mechanism of excitatory synaptic transmission. Moreover, NMDA receptors are widely involved in many forms of synaptic plasticity such as long-term potentiation (LTP) and long-term depression (LTD), which are thought to underlie complex tasks, including learning and memory. Dysfunction of these ligand-gated cation channels has been identified as an underlying molecular mechanism in… CONTINUE READING
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