On the hand-over-hand mechanism of kinesin.

  title={On the hand-over-hand mechanism of kinesin.},
  author={Qiang Shao and Yi Qin Gao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 21},
We present here a simple theoretical model for conventional kinesin. The model reproduces the hand-over-hand mechanism for kinesin walking to the plus end of a microtubule. A large hindering force induces kinesin to walk slowly to the minus end, again by a hand-over-hand mechanism. Good agreement is obtained between the calculated and experimental results on the external force dependence of the walking speed, the forward/backward step ratio, and dwell times for both forward and backward steps… CONTINUE READING

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