On the formation of homo‐aza‐steroids and derivatives by beckmann rearrangement. Antitumor activity of stereoisomers homo‐aza‐steroidal esters

@article{Catsoulacos1993OnTF,
  title={On the formation of homo‐aza‐steroids and derivatives by beckmann rearrangement. Antitumor activity of stereoisomers homo‐aza‐steroidal esters},
  author={P. Catsoulacos and D. Catsoulacos},
  journal={Journal of Heterocyclic Chemistry},
  year={1993},
  volume={30},
  pages={1-10}
}
  • P. Catsoulacos, D. Catsoulacos
  • Published 1993
  • Chemistry
  • Journal of Heterocyclic Chemistry
  • The Beckmann rearrangement of steroidal oximes is reported. Different methods of esterification of homo-aza-steroids with carboxylic derivatives of N,N-bis(2-chloroethyl)aniline are reported. The lipophilic nature of the steroidal hormones is the reason for searching compounds containing as the biological platform the steroid molecule and as the active moiety the alkylating agent, such as nitrogen mustards linked to the steroid with a stable bond or with an easily cleaved ester or ether… CONTINUE READING
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