On the formation of homo‐aza‐steroids and derivatives by beckmann rearrangement. Antitumor activity of stereoisomers homo‐aza‐steroidal esters

@article{Catsoulacos1993OnTF,
  title={On the formation of homo‐aza‐steroids and derivatives by beckmann rearrangement. Antitumor activity of stereoisomers homo‐aza‐steroidal esters},
  author={P. Catsoulacos and D. Catsoulacos},
  journal={Journal of Heterocyclic Chemistry},
  year={1993},
  volume={30},
  pages={1-10}
}
  • P. Catsoulacos, D. Catsoulacos
  • Published 1993
  • Chemistry
  • Journal of Heterocyclic Chemistry
    • The Beckmann rearrangement of steroidal oximes is reported. Different methods of esterification of homo-aza-steroids with carboxylic derivatives of N,N-bis(2-chloroethyl)aniline are reported. The lipophilic nature of the steroidal hormones is the reason for searching compounds containing as the biological platform the steroid molecule and as the active moiety the alkylating agent, such as nitrogen mustards linked to the steroid with a stable bond or with an easily cleaved ester or ether… CONTINUE READING
    View via Publisher
    9 Citations
    9 Citations
    Citation Type

    Citation Type

    Synthetic Applications of Conjugated Nitrones, 5 A Novel Entry to the 13‐Azasteroid System
    • 9
    Oxime and oximate metal complexes: unconventional synthesis and reactivity
    • 204
    • PDF
    Spectral and luminescent properties of 2,3-dimethoxy-8-aza-D-homogona-1,3,5(10),13-tetraene-12,17a-dione and its Δ9,11 derivative
    • 2
    METAL-ION ASSISTED REACTIONS OF OXIMES AND REACTIVITY OF OXIME-CONTAINING METAL COMPLEXES
    • 156
    Spectral and kinetic properties of an immunoactive 8-azasteroid and a product of its photochemical transformation in aqueous solutions
    Synthesis of photochromic 2,3-bis(2,5-dimethyl-3-thienyl)-3-cyanoacrylates by the Beckmann rearrangement of a cyclobutenedione derivative
    • 6
    The Literature of Heterocyclic Chemistry, Part V
    • 10
    Fast relaxation processes and structural changes in immunoactive biomolecules.
    • 3
    Formation of Homoazasteroids and Derivatives by Beckmann Rearrangement. Antitumor Activity of Stereoisomers Homoazasteroidal Esters

    References

    SHOWING 1-10 OF 25 REFERENCES
    Beckmann rearrangement of 3-aza-a-homo-4α-androsten-4,17-dione oxime and 3-oxo-13α-amino-13,17-seco-4-androsten-17-oic 13,17-lactam oxime
    • 6
    Activity of 17 beta-hydroxy-3-aza-A-homo-4 alpha-androsten-4-one-p-N, N-bis(2-chloroethyl)aminophenoxyacetate (NSC-620480) in P388 leukemia. Activity of steroidal lactams in Ehrlich tumor.
    • 3
    Response of Transplantable Tumors in Mice and of Macromolecular Synthesis to 17β-Acetamido-3-aza-A-homo-4α-androsten-4-one
    • 8
    Effect of a ▵5-Homo-Aza-Steroidal Ester in P388 and L1210 Murine Leukemias
    • 19
    Further studies on the anti-neoplastic activity of 3 β-hydroxy-13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam {p-[bis(2-chloroethyl)amino]-phenyl}acetate (NSC 290205)
    • 29
    Activity of 3β-Hydroxy-13α-Amino-13,17-Seco-5α-Androstane-17-oic-13,17-Lactam(p-(bis(2-Chloroethyl)amino)-Phenyl)acetate (NSC 290205) in Murine Solid Tumors
    • 31
    A partial synthesis of aldosterone.
    • 3
    Antineoplastic agents. V: Nitrogen mustards of systematically modified steroidal ring A lactams (1)
    • 17
    Synthesis of 17β-acetamido-3-aza-A-homo-4α-androsten-4-one
    • 4
    Steroids. Part XXXVI. Some 13,17-secoandrostanes
    • 2