• DOI:10.1016/s0021-9258(17)33789-4
Corpus ID: 24393630

On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase.

@article{Battula1976OnTF,
  title={On the fidelity of DNA replication. Lack of exodeoxyribonuclease activity and error-correcting function in avian myeloblastosis virus DNA polymerase.},
  author={N. Battula and L. Loeb},
  journal={The Journal of biological chemistry},
  year={1976},
  volume={251 4},
  pages={
          982-6
        }
}

N. Battula, L. Loeb

Published 1976

Medicine, Biology

The Journal of biological chemistry

Homogeneous DNA polymerase ("reverse transcriptase") from avian myeoblastosis virus was assayed for exodeoxyribonuclease activity. The substrates were defined template-initiator complexes in which different radioactive nucleotides were present at the 3'-OH termini of the initiator. Even when the number of molecules of enzyme was equal to the number of initiator termini there was no significant release of radioactivity with any of the template-initiator combinations tested. Under similar… CONTINUE READING

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