On the essentiality of lipopolysaccharide to Gram-negative bacteria.

@article{Zhang2013OnTE,
  title={On the essentiality of lipopolysaccharide to Gram-negative bacteria.},
  author={Ge Zhang and Timothy Charles Meredith and Daniel E Kahne},
  journal={Current opinion in microbiology},
  year={2013},
  volume={16 6},
  pages={779-85}
}
Lipopolysaccharide is a highly acylated saccharolipid located on the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharide is critical to maintaining the barrier function preventing the passive diffusion of hydrophobic solutes such as antibiotics and detergents into the cell. Lipopolysaccharide has been considered an essential component for outer membrane biogenesis and cell viability based on pioneering studies in the model Gram-negative organisms Escherichia coli… CONTINUE READING
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