Corpus ID: 8863185

On the effects and mechanism of action of the antihypertensive agent TR 3369 (5-methoxytryptamine beta-methylcarboxylate) in spontaneously hypertensive rats.

@article{Antonaccio1981OnTE,
  title={On the effects and mechanism of action of the antihypertensive agent TR 3369 (5-methoxytryptamine beta-methylcarboxylate) in spontaneously hypertensive rats.},
  author={M. Antonaccio and L. Kerwin},
  journal={Journal of cardiovascular pharmacology},
  year={1981},
  volume={3 6},
  pages={
          1306-11
        }
}
The effects of the serotonin (5-HT) analog TR 3369 (5-methoxytryptamine beta-methylcarboxylate) on blood pressure and heart rate of spontaneously hypertensive rats (SHR) were examined. In conscious SHR, TR 3369 caused reductions in blood pressure without importantly changing heart rate in doses ranging from 1 to 30 mg/kg p.o. TR 3369 was found to have no significant antagonistic effects on alpha-, beta-, or 5-HT receptors, nor did the drug inhibit adrenergic neuronal or ganglionic function. A… Expand