On the effect of the intracellular calcium-sensitive K+ channel in the bursting pancreatic beta-cell.

Based on the observation that the calcium-activated K+ channel in the pancreatic islet cells can also be activated by the membrane potential, we have formulated a mathematical model for the electrical activity in the pancreatic beta-cell. Our model contains two types of ionic channels, which are active above the subthreshold glucose concentration in the… CONTINUE READING