On the effect of a point mutation on the reactivity of CuZn superoxide dismutase: a theoretical study.

Abstract

In this paper, we investigate the effects of a point mutation on the enzymatic activity of copper-zinc superoxide dismutase, which we recently studied in detail by means of a theoretical-computational procedure. Comparison of the reactivity of the initial catalytic steps in this mutant (G93A mutation far from the active site) with our previous data, reveals the beautiful mechanical-dynamical architecture of the enzyme, altered by such an apparently irrelevant mutation. Finally, our results suggest a possible atomic-molecular-based explanation for the mutant-pathology correlation, in line with the most recent experimental data.

Cite this paper

@article{Amadei2006OnTE, title={On the effect of a point mutation on the reactivity of CuZn superoxide dismutase: a theoretical study.}, author={Andrea Amadei and Maira D'Alessandro and Maurizio Paci and Alfredo di Nola and Massimiliano Aschi}, journal={The journal of physical chemistry. B}, year={2006}, volume={110 14}, pages={7538-44} }