On the dynamic nature of the transition state for protein-protein association as determined by double-mutant cycle analysis and simulation.

@article{Harel2007OnTD,
  title={On the dynamic nature of the transition state for protein-protein association as determined by double-mutant cycle analysis and simulation.},
  author={Michal Harel and Mati Cohen and Gideon Schreiber},
  journal={Journal of molecular biology},
  year={2007},
  volume={371 1},
  pages={
          180-96
        }
}
The process of protein-protein association starts with their random collision, which may develop into an encounter complex followed by a transition state and final complex formation. Here we aim to experimentally characterize the nature of the transition state of protein-protein association for three different protein-protein interactions; Barnase-Barstar, TEM1-BLIP and IFNalpha2-IFNAR2, and use the data to model the transition state structures. To model the transition state, we determined… CONTINUE READING
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