On the correlation between hydrophobicity, liposome binding and cellular uptake of porphyrin sensitizers.

@article{BenDror2006OnTC,
  title={On the correlation between hydrophobicity, liposome binding and cellular uptake of porphyrin sensitizers.},
  author={Shimshon Ben-Dror and Irena Bronshtein and Arno Wiehe and Beate Roeder and Mathias O. Senge and Benjamin Ehrenberg},
  journal={Photochemistry and photobiology},
  year={2006},
  volume={82 3},
  pages={695-701}
}
A crucial factor in choosing a porphyrin or analogous photosensitizer for photodynamic therapy (PDT) is its ability to incorporate into the cells. For hydrophobic compounds that partition passively into the cytoplasmic membrane, a partition coefficient between an organic solvent and water, P, is one factor that could be used to predict the molecule's ability to diffuse into biomembranes. We synthesized several porphyrins, modified with two, three or four meso-substituents and studied their… CONTINUE READING