On the conservation of function of the Drosophila Fat facets deubiquitinating enzyme and Fam, its mouse homolog

@article{Chen2000OnTC,
  title={On the conservation of function of the Drosophila Fat facets deubiquitinating enzyme and Fam, its mouse homolog},
  author={X. Chen and Erin Camille Overstreet and Stephen A Wood and Janice A. Fischer},
  journal={Development Genes and Evolution},
  year={2000},
  volume={210},
  pages={603-610}
}
Fat facets is a Drosophila deubiquitinating enzyme required for eye development and early embryogenesis. Genetic evidence suggests that Fat facets deubiquitinates and thereby prevents the proteasomal degradation of specific substrates. The Drosophila Liquid facets protein is implicated as the critical substrate of Fat facets in the eye. A mouse homolog of Fat facets, called Fam, has been identified. The results of biochemical experiments implicate two different proteins, Af-6 and β-catenin, as… CONTINUE READING

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The function of the Drosophila Fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis

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