On the conformation of the anticodon loops of initiator and elongator methionine tRNAs.

@article{Schweisguth1997OnTC,
  title={On the conformation of the anticodon loops of initiator and elongator methionine tRNAs.},
  author={D C Schweisguth and Peter B Moore},
  journal={Journal of molecular biology},
  year={1997},
  volume={267 3},
  pages={
          505-19
        }
}
The solution conformations of analogues of initiator and elongator tRNA anticodon stem-loops have been compared by NMR. The data indicate that both have conformations closely similar to those reported for crystalline elongator tRNAs. The two loops differ in their dynamics, however: that of the elongator analogue is more flexible than its initiator counterpart. The anticodon stem-loops of initiator tRNAs are more likely to be distinguished from those of elongator tRNAs during initiation on the… 
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A unique conformation of the anticodon stem-loop is associated with the capacity of tRNAfMet to initiate protein synthesis
TLDR
The crystal structure of Escherichia coli initiator tRNAfMet has been solved and reveals a unique structure, which has not been described in any other tRNA, which suggests a mechanism by which the translation initiation machinery could discriminate the initiators tRNA from all other tRNAs.
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The loop conformation differs from that seen in tRNA(Phe) and provides an explanation of the critical role of modification in this tRNA.
A critical role of water in the specific cleavage of the anticodon loop of some eukaryotic methionine initiator tRNAs
TLDR
It is concluded that a single nucleotide change in the primary structure of tRNAMeti made changes in hydration pattern and readjustment in hydrogen bonding which lead to a cleavage of the phosphodiester bond.
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Involvement of 16S rRNA nucleotides G1338 and A1339 in discrimination of initiator tRNA.
Synthesis and biophysical characterization of tRNA(Lys,3) anticodon stem-loop RNAs containing the mcm(5)s(2)U nucleoside.
TLDR
Standard RNA phosphoramidite coupling chemistry allowed us to systematically investigate the thermodynamic effects of nucleoside modification and to correlate thermodynamic trends with qualitative structure effects seen by NMR spectroscopy.
The transorientation hypothesis for codon recognition during protein synthesis
TLDR
A molecular mechanism for the decoding phase of translation: the transorientation hypothesis is proposed, which incorporates a newly identified tRNA binding site and utilizes a flip between two tRNA anticodon loop structures, the 5′-stacked and the 3′-Stacked conformations.
Programmed translational −1 frameshifting on hexanucleotide motifs and the wobble properties of tRNAs
TLDR
Two classes of NNA codons were distinguished, depending on whether they favor or limit frameshifting, and their degree of shiftiness is correlated with wobble propensity, and base 34 modification, of their decoding tRNAs.
Arginyl-tRNA Modifications Modulate Anticodon Domain Structure, Function and Dynamics in Escherichia coli.
TLDR
It is shown conclusively that modifications can act to restrict the decoding capability of the tRNAs to only the two common codons, suggesting that the tRNA is present at high levels, consistent with decoding commoncodons, but that there is a smaller pool of tRNA in different states of modification, corresponding to decoding of the rare codon.
Singly and bifurcated hydrogen-bonded base-pairs in tRNA anticodon hairpins and ribozymes.
TLDR
The data demonstrate the conservation of a bifurcated hydrogen bond interaction between residues 32 and 38, located at the stem/loop junction, which leads to the formation of a non-canonical base-pair which is preserved in the known crystal structures of tRNA/synthetase complexes.
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References

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Initiator tRNAs have an anticodon loop conformation distinct from that of elongation tRNAs as detected by susceptibility to S1 nuclease. We now find the anticodon loop conformation of E. coli…
Initiator tRNAs have a unique anticodon loop conformation.
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TLDR
It is suggested that the specialized conformation in the anticodon loop of initiator tRNAs may be due to a special sequence of GC base pairs in the adjoining anticodon stem.
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TLDR
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TLDR
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The crystal structure of Escherichia coli tRNAfMet an initiator transfer RNA, has been determined. While grossly similar to that of the chain-elongating yeast tRNAPhe, there are three major…
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The crystal structure of Escherichia coli glutaminyl-tRNA synthetase (GlnRS) complexed with its cognate glutaminyl transfer RNA (tRNA(Gln] and adenosine triphosphate (ATP) has been derived from a 2.8…
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TLDR
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TLDR
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TLDR
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