On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia.

  title={On the clinical and cognitive meaning of impaired sensorimotor gating in schizophrenia.},
  author={Michael E. Dawson and Anne M. Schell and Erin A. Hazlett and Keith H. Nuechterlein and Diane L. Filion},
  journal={Psychiatry research},
  volume={96 3},
Schizophrenia patients have been shown to have a defective sensorimotor gating process as indexed by impaired prepulse inhibition of the startle eyeblink reflex. Moreover, we have previously reported that schizophrenia patients have dysfunctional attentional modulation of prepulse inhibition. The present experiment combined our previous sample of 14 schizophrenia outpatients and 12 demographically matched control subjects with a new sample of 10 outpatients and 6 control subjects. All… CONTINUE READING
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