On the classification of epistatic interactions.

@article{Gao2010OnTC,
  title={On the classification of epistatic interactions.},
  author={Hong Gao and Julie M. Granka and Marcus W. Feldman},
  journal={Genetics},
  year={2010},
  volume={184 3},
  pages={827-37}
}
Modern genomewide association studies are characterized by the problem of "missing heritability." Epistasis, or genetic interaction, has been suggested as a possible explanation for the relatively small contribution of single significant associations to the fraction of variance explained. Of particular concern to investigators of genetic interactions is how to best represent and define epistasis. Previous studies have found that the use of different quantitative definitions for genetic… CONTINUE READING
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