Corpus ID: 30214127

On the central antiserotonin activity of benzoctamine and opipramol.

@article{Przegaliski1978OnTC,
  title={On the central antiserotonin activity of benzoctamine and opipramol.},
  author={Edmund Przegaliński and Leokadia Baran and W. Palider and K Bigajska},
  journal={Polish journal of pharmacology and pharmacy},
  year={1978},
  volume={30 6},
  pages={
          781-90
        }
}
Benzoctamine inhibited the head twitch reaction induced by L-5-hydroxytryptophan (5-HTP) in mice and by 5-methoxytryptamine (5-MT) in rats pretreated with tranylcypromine. It also antagonized tryptamine (TRP)-induced clonic convulsions of forepaws in rats. Opipramol had no effect in the 5-MT test and appeared to be a weak antagonist in the 5-HTP and TRP tests. Both drugs, of which benzoctamine was a more potent antagonist, inhibited hyperthermia induced by LSD in rabbits. Benzoctamine abolished… Expand
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