Corpus ID: 30214127

On the central antiserotonin activity of benzoctamine and opipramol.

  title={On the central antiserotonin activity of benzoctamine and opipramol.},
  author={Edmund Przegaliński and Leokadia Baran and W. Palider and K Bigajska},
  journal={Polish journal of pharmacology and pharmacy},
  volume={30 6},
Benzoctamine inhibited the head twitch reaction induced by L-5-hydroxytryptophan (5-HTP) in mice and by 5-methoxytryptamine (5-MT) in rats pretreated with tranylcypromine. It also antagonized tryptamine (TRP)-induced clonic convulsions of forepaws in rats. Opipramol had no effect in the 5-MT test and appeared to be a weak antagonist in the 5-HTP and TRP tests. Both drugs, of which benzoctamine was a more potent antagonist, inhibited hyperthermia induced by LSD in rabbits. Benzoctamine abolished… Expand
3 Citations
Changes in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: II
  • W. G. Clark
  • Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1987
This compilation primarily covers the considerable amount of data published from 1981 through 1985 on the interactions of these drugs and thermoregulation, but data from many earlier papers not included in a previous compilation are also tabulated. Expand
The in vivo and in vitro occupation of [3H]-spiperone binding sites in the frontal cortex and striatum by putative 5-hydroxytryptamine antagonists
The results indicate a binding site heterogeneity consistent with the labelling of both 5-HT and dopamine (DA) receptors by [ 3 H]-spiperone both in vitro and in vivo. Expand
Changes in body temperature after administration of amino acids, peptides, dopamine, neuroleptics and related agents
  • W. G. Clark
  • Medicine, Chemistry
  • Neuroscience & Biobehavioral Reviews
  • 1980
The study of drug-induced changes in body temperature has expanded greatly within the past decade and the cited literature is a readily available source of information on interactions between certain drugs and the thermoregulatory system. Expand