On the bacterial ancestry of mitochondria: new insights with triangulated approaches

  title={On the bacterial ancestry of mitochondria: new insights with triangulated approaches},
  author={Michelle Degli Esposti and Otto Geiger and Alejandro S{\'a}nchez-Flores and Mauro Degli Esposti},
We breathe at the molecular level when mitochondria in our cells consume oxygen to extract energy from nutrients. Mitochondria are characteristic cellular organelles that derive from aerobic bacteria similar to some of those thriving in the oceans nowadays. These organelles carry out most metabolic pathways in eukaryotic cells. The precise bacterial origin of mitochondria and, consequently, the metabolic ancestry of our cells remains controversial - despite the vast genomic information that is… 
1 Citations

The Genus Iodidimonas: From Its Discovery to Potential Applications

The genus Iodidimonas was recently proposed in the class Alphaproteobacteria. Iodidimonas strains are aerobic, mesophilic, neutrophilic, moderately halophilic, and chemo-organotrophic. They were



Bioenergetic Evolution in Proteobacteria and Mitochondria

Previously overlooked information on methanotrophic bacteria, in particular their intracytoplasmic membranes resembling mitochondrial cristae and their capacity of establishing endosymbiotic relationships with invertebrate animals and archaic plants are discussed.

Evolution of Mitochondria Reconstructed from the Energy Metabolism of Living Bacteria

It is shown that methylotrophic α-proteobacteria could be the closest living models for mitochondrial ancestors and provide a new perspective for experimentally re-evolving mitochondria from extant bacteria and in the future produce synthetic mitochondria.

Mitochondrial evolution.

  • M. Gray
  • Biology
    Cold Spring Harbor perspectives in biology
  • 2012
New data continue to reshape views regarding mitochondrial evolution, particularly raising the question of whether the mitochondrion originated after the eukaryotic cell arose, as assumed in the classical endosymbiont hypothesis, or whether this organelle had its beginning at the same time as the cell containing it.

Deep mitochondrial origin outside the sampled alphaproteobacteria

It is suggested that mitochondria evolved from a proteobacterial lineage that branched off before the divergence of all sampled alphaproteobacteria and previous hypotheses on the nature of the mitochondrial ancestor should be re-evaluated.

Eukaryogenesis and oxygen in Earth history.

Together, these results temporally, spatially and metabolically decouple the earliest stages of eukaryogenesis from the oxygen content of the surface ocean and atmosphere.

Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis

It is demonstrated that RquA functions in the mitochondrion-related organelles of the anaerobic protist Pygsuia and is correlated with the presence of RQ, revealing the role of gene transfer in the evolutionary remodeling of mitochondria in adaptation to hypoxia.

Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae

This work uses single-cell genomics from natural samples combined with phylogenomics to infer the evolutionary origin of the phylum Picozoa, a globally distributed but seemingly rare group of marine microbial heterotrophic eukaryotes and indicates that red algae and rhodelphids obtained their plastids independently of other archaeplastids.

Advances in bacterial pathways for the biosynthesis of ubiquinone.

Respiratory Heme A-Containing Oxidases Originated in the Ancestors of Iron-Oxidizing Bacteria

It is suggested that the ancestors of extant iron-oxidizers were the first to evolve COX and lived on emerged land around the time for which there is the earliest geochemical evidence of aerobic respiration on earth.

Site-and-branch-heterogeneous analyses of an expanded dataset favour mitochondria as sister to known Alphaproteobacteria.

A new model of protein evolution that accommodates both across-site and across-branch compositional heterogeneity and suggests that mitochondria are sister to the Alphaproteobacteria to the exclusion of MarineProteo1 and Magnetococcia.