On the assessment of bioequivalence in a two-period cross-over design.

@article{Wijnand1992OnTA,
  title={On the assessment of bioequivalence in a two-period cross-over design.},
  author={Herman P. Wijnand},
  journal={Computer methods and programs in biomedicine},
  year={1992},
  volume={37 2},
  pages={151-7}
}
The results obtained with Meineke and De Mey's algorithm for posterior probability distributions in the nonparametric evaluation of two-period cross-over bioequivalence studies are critically discussed. Suggestions for improvement of their program NEWPARM are given. It is shown that this program in its present form cannot handle the results from bioequivalence studies in which more than 15 subjects participated. For larger study sizes, conversion to a more powerful programming language capable… CONTINUE READING

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