On the application of compartmental models to radioactive tracer kinetic studies of in vivo protein turnover in animals.

@article{France1988OnTA,
  title={On the application of compartmental models to radioactive tracer kinetic studies of in vivo protein turnover in animals.},
  author={James France and C Christopher Calvert and Robert L. Baldwin and Kirk C. Klasing},
  journal={Journal of theoretical biology},
  year={1988},
  volume={133 4},
  pages={447-71}
}
A mathematical framework is presented for unifying and extending the various compartmental models and formulae used to calculate fractional protein synthesis and degradation rates in animals from data obtained by infusing labelled amino acids. It is shown how the various schemes can be derived as special cases of the product-precursor model or some three-pool variant. Three-compartment representations, which circumvent the need to measure the specific radioactivity of the precursor pool, are… CONTINUE READING

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