On the anticonvulsant effect of allopregnanolone (a neurosteroid) in neonatal rats.

AIMS Allopregnanolone has shown potent anticonvulsant activity in the adult brain. However, none of the studies have shown its effect in neonatal animal models of seizures. The current study explored the effect of allopregnanolone in animal models of neonatal status epilepticus. MAIN METHODS Allopregnanolone was administered 10min before administration of… CONTINUE READING