On the action potential as a propagating density pulse and the role of anesthetics

  title={On the action potential as a propagating density pulse and the role of anesthetics},
  author={Thomas Heimburg and Andrew D. Jackson},
The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channe ls. We discuss a number of classical thermodynamic findings on ne rves that are not contained in this classical theory. Partic ularly striking is the finding of reversible heat changes, thicknes s and phase changes of the membrane during the action potenti al. Data on various nerves rather suggest that a reversible density p ulse accompanies the action potential of nerves… CONTINUE READING


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