On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni

  title={On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni},
  author={Leonardo Paiva Farias and Greice Krautz-Peterson and Cibele Aparecida Tararam and Bogar O. Araujo-Montoya and Tatiana Rodrigues Fraga and Henrique Krambeck Rofatto and Floriano Paes Silva-Jr and Lourdes Isaac and Akram A. Da'dara and R Alan Wilson and Charles B Shoemaker and Luciana Cezar de Cerqueira Leite},
  booktitle={PLoS neglected tropical diseases},
BACKGROUND It is believed that schistosomes evade complement-mediated killing by expressing regulatory proteins on their surface. Recently, six homologues of human CD59, an important inhibitor of the complement system membrane attack complex, were identified in the schistosome genome. Therefore, it is important to investigate whether these molecules could act as CD59-like complement inhibitors in schistosomes as part of an immune evasion strategy. METHODOLOGY/PRINCIPAL FINDINGS Herein, we… CONTINUE READING
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PROCHECK: a program to check the stereochemical quality of protein structures

  • RA Laskowski, MW MacArthur, DS Moss, JM Thornton
  • Journal of Applied Crystallography
  • 1993
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