On the Sequence of Bond Formation in Loline Alkaloid Biosynthesis

@article{Faulkner2006OnTS,
  title={On the Sequence of Bond Formation in Loline Alkaloid Biosynthesis},
  author={Jerome R. Faulkner and S. Hussaini and J. D. Blankenship and Sitaram Pal and B. Branan and R. B. Grossman and C. Schardl},
  journal={ChemBioChem},
  year={2006},
  volume={7}
}
Loline alkaloids are saturated pyrrolizidines with an oxygen bridge between carbon atoms C‐2 and C‐7 and an amino group on C‐1. They are bioprotective alkaloids produced by Epichloë and Neotyphodium species, mutualistic fungal endophytes that are symbiotic with cool‐season grasses. The sequence of bond formation in loline alkaloid biosynthesis was determined by synthesizing deuterated forms of potential intermediates and feeding them to cultures of the endophyte Neotyphodium uncinatum. These… Expand
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