On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition.

@article{Lamers2016OnTP,
  title={On the Physicochemical and Structural Modifications Associated with HIV-1 Subtype B Tropism Transition.},
  author={Susanna L. Lamers and Gary B. Fogel and Enoch S. Liu and Marco Salemi and Michael S. McGrath},
  journal={AIDS research and human retroviruses},
  year={2016},
  volume={32 8},
  pages={829-40}
}
HIV-1 enters immune cells via binding the viral envelope to a host cell CD4 receptor, and then a secondary co-receptor, usually CCR5 (R5) or CXCR4 (X4), and some HIV can utilize both co-receptors (R5X4). Although a small set of amino-acid properties such as charge and sequence length applied to HIV-1 envelope V3 loop sequence data can be used to predict co-receptor usage, we sought to expand the fundamental understanding of the physiochemical basis of tropism by analyzing many, perhaps less… CONTINUE READING

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