On the Origin of Leprosy

@article{Monot2005OnTO,
  title={On the Origin of Leprosy},
  author={M. Monot and N. Honor{\'e} and T. Garnier and R. Aráoz and J. Copp{\'e}e and C. Lacroix and S. Sow and J. Spencer and R. Truman and D. L. Williams and R. Gelber and M. Virmond and B. Flageul and S. Cho and B. Ji and A. Paniz-Mondolfi and J. Convit and Saroj K. Young and P. Fine and V. Rasolofo and P. Brennan and S. Cole},
  journal={Science},
  year={2005},
  volume={308},
  pages={1040 - 1042}
}
Leprosy, a chronic human disease with potentially debilitating neurological consequences, results from infection with Mycobacterium leprae. This unculturable pathogen has undergone extensive reductive evolution, with half of its genome now occupied by pseudogenes. Using comparative genomics, we demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms. The disease… Expand
260 Citations
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