On the Origin of Iron/Sulfur Cluster Biosynthesis in Eukaryotes

  title={On the Origin of Iron/Sulfur Cluster Biosynthesis in Eukaryotes},
  author={A. Tsaousis},
  journal={Frontiers in Microbiology},
  • A. Tsaousis
  • Published 2019
  • Chemistry, Medicine
  • Frontiers in Microbiology
Iron and sulfur are indispensable elements of every living cell, but on their own these elements are toxic and require dedicated machineries for the formation of iron/sulfur (Fe/S) clusters. In eukaryotes, proteins requiring Fe/S clusters (Fe/S proteins) are found in or associated with various organelles including the mitochondrion, endoplasmic reticulum, cytosol, and the nucleus. These proteins are involved in several pathways indispensable for the viability of each living cell including DNA… Expand
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