On the Nadeau-Taylor Theory of Conserved Chromosome Segments

@inproceedings{Sankoff1997OnTN,
  title={On the Nadeau-Taylor Theory of Conserved Chromosome Segments},
  author={David Sankoff and Marie-Noelle Parent and Isabelle Marchand and Vincent Ferretti},
  booktitle={CPM},
  year={1997}
}
The quantification of comparative genomics dates from 1984 with the work of Nadeau and Taylor on estimating interchromosomal exchange rates based on the rearrangement of chromosomal segments in human versus mouse genomes. We reformulate their analysis in terms of a probabilistic model based on spatial homogeneity and independence of breakpoints and gene distribution. We study the marginal distribution of the number of genes per segment and the distribution of the number of nonempty segments as… CONTINUE READING
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