On the Formation of Bile Pigments from Heme Proteins


It is proposed that the oatabolism of heme to biliverdin involves an initial epoxidation of a protein-bound porphyrin at the exposed g-methine bridge. Rearrangement of thegto an a-epoxide followed by ring opening to a homooxaporph yrin would generate an electron-rich system capable of reacting with molecular oxygen to form a dioxetane. Fragmentation of the… (More)


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