On the Evolution of Redundancy in Genetic Codes

@article{Ardell2001OnTE,
  title={On the Evolution of Redundancy in Genetic Codes},
  author={David H. Ardell and Guy Sella},
  journal={Journal of Molecular Evolution},
  year={2001},
  volume={53},
  pages={269-281}
}
We simulate a deterministic population genetic model for the coevolution of genetic codes and protein-coding genes. We use very simple assumptions about translation, mutation, and protein fitness to calculate mutation-selection equilibria of codon frequencies and fitness in a large asexual population with a given genetic code. We then compute the fitnesses of altered genetic codes that compete to invade the population by translating its genes with higher fitness. Codes and genes coevolve in a… CONTINUE READING
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