[On the Effect of α-Tocopherol on Protein Kinase C Activity in vitro].

Abstract

The effect of the antioxidant α-tocopherol on rat brain protein kinase C activity as a model to study bimodal dose-dependent effect has been investigated. Enzyme activity has been monitored photometrically with a luciferase reporter assay that measures ADP produced by posphorylation. The inhibition of protein kinase C activity by α-tocopherol was found at the concentration range from 10(-3) to 10(-6) M with no effect of ultra low doses of the antioxidant (below. 10(-12) M). The absence of bimodal dose-dependent effect may be associated with the enzyme source.

Cite this paper

@article{Krassova2015OnTE, title={[On the Effect of α-Tocopherol on Protein Kinase C Activity in vitro].}, author={N E Krassova and S V Ugraitskaya and Nikita Penkov and Evgeny E. Fesenko}, journal={Biofizika}, year={2015}, volume={60 5}, pages={1036-8} }