On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations

@article{Renzette2016OnTA,
  title={On the Analysis of Intrahost and Interhost Viral Populations: Human Cytomegalovirus as a Case Study of Pitfalls and Expectations},
  author={Nicholas Renzette and Susanne P. Pfeifer and Sebastian Matuszewski and Timothy F. Kowalik and Jeffrey D. Jensen},
  journal={Journal of Virology},
  year={2016},
  volume={91}
}
ABSTRACT Intrahost and interhost assessments of viral diversity are often treated as measures of separate and distinct evolutionary processes, with numerous investigations reporting seemingly incompatible results between the two. For example, in human cytomegalovirus, the nucleotide diversity estimates are 10-fold higher for interhost data, while the number of segregating (i.e., polymorphic) sites is 6-fold lower. These results have been interpreted as demonstrating that sampled intrahost… 
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