On testing simultaneously non-inferiority in two multiple primary endpoints and superiority in at least one of them.

@article{Rhmel2006OnTS,
  title={On testing simultaneously non-inferiority in two multiple primary endpoints and superiority in at least one of them.},
  author={Joachim R{\"o}hmel and Christoph Gerlinger and Norbert Benda and J{\"u}rgen L{\"a}uter},
  journal={Biometrical journal. Biometrische Zeitschrift},
  year={2006},
  volume={48 6},
  pages={916-33}
}
In a clinical trial with an active treatment and a placebo the situation may occur that two (or even more) primary endpoints may be necessary to describe the active treatment's benefit. The focus of our interest is a more specific situation with two primary endpoints in which superiority in one of them would suffice given that non-inferiority is observed in the other. Several proposals exist in the literature for dealing with this or similar problems, but prove insufficient or inadequate at a… CONTINUE READING

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