On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.

@article{Stechishin2013OntargetJI,
  title={On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.},
  author={Owen D. M. Stechishin and Hema Artee Luchman and Yibing Ruan and Michael D Blough and Stephanie A. Nguyen and John P. J. Kelly and J. Gregory Cairncross and Samuel A Weiss},
  journal={Neuro-oncology},
  year={2013},
  volume={15 2},
  pages={198-207}
}
BACKGROUND Glioblastoma multiforme (GBM) is characterized by an aggressive clinical course, therapeutic resistance, and striking molecular heterogeneity. GBM-derived brain tumor stem cells (BTSCs) closely model this molecular heterogeneity and likely have a key role in tumor recurrence and therapeutic resistance. Emerging evidence indicates that Janus kinase (JAK)2/signal transducer and activator of transcription (STAT)3 is an important mediator of tumor cell survival, growth, and invasion in a… CONTINUE READING