On-site energy supply at synapses through monocarboxylate transporters maintains excitatory synaptic transmission.

@article{Nagase2014OnsiteES,
  title={On-site energy supply at synapses through monocarboxylate transporters maintains excitatory synaptic transmission.},
  author={Masashi Nagase and Yukari Takahashi and Ayako M. Watabe and Yoshihiro Kubo and Fusao Kato},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 7},
  pages={2605-17}
}
ATP production through oxidative phosphorylation in the mitochondria is the most efficient way to provide energy to various energy-consuming activities of the neurons. These processes require a large amount of ATP molecules to be maintained. Of these, synaptic transmission is most energy consuming. Here we report that lactate transported through monocarboxylate transporters (MCTs) at excitatory synapses constitutively supports synaptic transmission, even under conditions in which a sufficient… CONTINUE READING