On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells

@inproceedings{AvrahamDavidi2013OnsiteEO,
  title={On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells},
  author={Inbal Avraham-Davidi and Simon Yona and Myriam Grunewald and Limor Landsman and Cl{\'e}ment Cochain and Jean S{\'e}bastien Silvestre and Haim Mizrahi and Mohammad Faroja and Dalit Strauss-Ayali and Matthias Mack and Steffen Jung and E. Keshet},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Adult neovascularization relies on the recruitment of monocytes to the target organ or tumor and functioning therein as a paracrine accessory. The exact origins of the recruited monocytes and the mechanisms underlying their plasticity remain unclear. Using a VEGF-based transgenic system in which genetically tagged monocytes are conditionally summoned to the liver as part of a VEGF-initiated angiogenic program, we show that these recruited cells are derived from the abundant pool of circulating… CONTINUE READING
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