On recent meta-analyses of exposure to glyphosate and risk of non-Hodgkin's lymphoma in humans.

  title={On recent meta-analyses of exposure to glyphosate and risk of non-Hodgkin's lymphoma in humans.},
  author={Geoffrey C Kabat and William J. Price and RobertE. Tarone},
  journal={Cancer causes \& control : CCC},
PURPOSE A recent meta-analysis of five case-control studies and one cohort study reported that exposure to glyphosate was associated with increased risk of non-Hodgkin's lymphoma (NHL). The meta-analysis was based on estimates of risk from the included studies at the highest reported exposure level obtained from analyses with the longest lag period. The extent to which the summary estimate depends upon the exposure definitions and assumed latency period is uncertain. METHODS We carried out… 
Exposure to glyphosate and risk of non-hodgkin lymphoma: an updated meta-analysis
This updated meta-analysis reinforces the previous conclusion of a lack of an association between exposure to glyphosate and risk of NHL overall, although an association with DLBCL cannot be ruled out.
Using the Matrix to bridge the epidemiology/risk assessment gap: a case study of 2,4-D
The use of the Matrix as a foundation for communication and education across disciplines could produce more impactful and consequential epidemiology research for robust risk assessments and decision-making.
Glyphosate-Based Herbicides and Public Health: Making Sense of the Science
  • S. Krimsky
  • Journal of Agricultural and Environmental Ethics
  • 2021


Glyphosate use and associations with non-Hodgkin lymphoma major histological sub-types: findings from the North American Pooled Project.
There was some limited evidence of an association between glyphosate use and NHL in this pooled analysis of case-control studies, but consistent patterns of association across different metrics were not observed.
Meat intake and non-Hodgkin lymphoma: a meta-analysis of observational studies
The observed positive association between red meat consumption and NHL is mainly supported by the effect estimates coming from case–control studies and is affected by multiple sources of heterogeneity.
Pesticide exposure as risk factor for non‐Hodgkin lymphoma including histopathological subgroup analysis
An association between exposure to phenoxyacetic acids and NHL and the association with glyphosate was considerably strengthened and confirmed an association between exposures to pesticides and NHL was confirmed.
Vitamin C Intake and Pancreatic Cancer Risk: A Meta-Analysis of Published Case-Control and Cohort Studies
There is insufficient evidence to conclude any relationship between vitamin C intake and risk of pancreatic cancer, and the strong inverse association observed in case-control studies may be affected by biases (eg, recall and selection biases) that particularly affect case- control studies and/or potential publication bias.
Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study
The results provide limited support to the hypothesis of an increase in risk of specific lymphoma subtypes associated with exposure to pesticides.
Exposure to Pesticides as Risk Factor for Non-Hodgkin's Lymphoma and Hairy Cell Leukemia: Pooled Analysis of Two Swedish Case-control Studies
For several categories of pesticides the highest risk was found for exposure during the latest decades before diagnosis, however, in multivariate analyses the only significantly increased risk was for a heterogeneous category of other herbicides than above.
Glyphosate Use and Cancer Incidence in the Agricultural Health Study
In this large, prospective cohort study, no association was apparent between glyphosate and any solid tumors or lymphoid malignancies overall, including NHL and its subtypes, and among applicators in the highest exposure quartile, there was some evidence of increased risk of AML among the highest exposed group that requires confirmation.
The Potential Effects of Recall Bias and Selection Bias on the Epidemiological Evidence for the Carcinogenicity of Glyphosate
  • K. Crump
  • Biology
    Risk analysis : an official publication of the Society for Risk Analysis
  • 2019
The results comply closely with what would be expected if evidence for carcinogenicity of glyphosate in these studies results from statistical bias in the case–control studies.
A meta-analysis of studies of dietary fat and breast cancer risk.
Regression analysis showed that European studies were more likely than studies done in other countries to show an increased relative risk associated with dietary fat and breast cancer, after taking into account potential modifying factors that included study design and quality.