On phagosome individuality and membrane signalling networks.

@article{Griffiths2004OnPI,
  title={On phagosome individuality and membrane signalling networks.},
  author={Gareth Griffiths},
  journal={Trends in cell biology},
  year={2004},
  volume={14 7},
  pages={343-51}
}
Cells such as macrophages take up pathogens into specialized membrane organelles (phagosomes) that fuse with other organelles, including lysosomes, in a process termed maturation. The fully matured phagolysosome is a low-pH, hydrolase-rich killing device that some pathogens can bypass. One might expect that phagosomes containing a given type of particle that entered cells simultaneously via the same receptor would behave the same, at least in a single cell. Surprisingly, however, recent data… CONTINUE READING

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