On-off response. Clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients.

@article{Shoulson1975OnoffRC,
  title={On-off response. Clinical and biochemical correlations during oral and intravenous levodopa administration in parkinsonian patients.},
  author={Ira Shoulson and G A Glaubiger and Thomas N. Chase},
  journal={Neurology},
  year={1975},
  volume={25 12},
  pages={1144-8}
}
Seven parkinsonian patients who had severe on-off effects during chronic treatment with levodopa were studied. Marked swings in plasma dopa levels as well as in motor function followed each oral dose of levodopa. A constant intravenous infusion of levodopa resulted in stable plasma dopa concentrations and virtual disappearance of motor fluctuations. Notwithstanding steady plasma dopa levels, an abrupt decline in the antiparkinsonian response to levodopa attended postural tilting or cold… CONTINUE READING

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