On-off phenomenon: relation to levodopa pharmacokinetics and pharmacodynamics.

  title={On-off phenomenon: relation to levodopa pharmacokinetics and pharmacodynamics.},
  author={John G. Nutt},
  journal={Annals of neurology},
  volume={22 4},
Motor function in the moderately to severely affected parkinsonian patient is critically dependent upon delivery of levodopa to the striatum. This, in turn, is influenced by the fluctuating plasma concentrations of levodopa produced by the drug's short half-life and erratic absorption, and by modifiable transport at the blood-brain barrier. Duration of response to a single dose of levodopa is proportional to peak plasma drug levels, and paradoxical responses may occur when plasma concentrations… CONTINUE READING

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